Contextual Fear Conditioning
Objective: Assessment of cognitive function and learning through contextual fear conditioning in aged mice to evaluate the effects of young blood plasma on age-related cognitive impairments
This is a Contextual Fear Conditioning protocol using mouse as the model organism. The procedure involves 1 procedural steps. Extracted from a 2014 paper published in Nature Medicine.
Model and subjects
mouse • Not specified in provided text • unknown • aged mice • Not specified in provided text
Study window
Estimated timing pending
Core workflow
Contextual Fear Conditioning Assessment
Primary readouts
- Age-related cognitive impairments in contextual fear conditioning
- Cognitive function improvement following young blood plasma administration
- Synaptic plasticity changes in hippocampus
- Dendritic spine density of mature neurons
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Contextual Fear Conditioning Assessment
Aged mice were assessed using contextual fear conditioning to measure cognitive function and learning
Note: This was one of two cognitive tests performed; spatial learning and memory was the other test
View evidence from paper
“systemic administration of young blood plasma into aged mice improved age-related cognitive impairments in both contextual fear conditioning and spatial learning and memory”