Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice

Saul A Villeda, Kristopher E Plambeck, Jinte Middeldorp, Joseph M Castellano, Kira I Mosher et al.

Nature Medicine • 2014

DOI PMC

Contextual Fear Conditioning

behavioralmouseNot specified in provided text

Objective: Assessment of cognitive function and learning through contextual fear conditioning in aged mice to evaluate the effects of young blood plasma on age-related cognitive impairments

Protocol Steps

Contextual Fear Conditioning Assessment

Aged mice were assessed using contextual fear conditioning to measure cognitive function and learning

Not specified in provided textNot specified in provided text

Note: This was one of two cognitive tests performed; spatial learning and memory was the other test

View evidence from paper

“systemic administration of young blood plasma into aged mice improved age-related cognitive impairments in both contextual fear conditioning and spatial learning and memory”