Contextual Fear Extinction Task
behavioralmouseNot specified in provided text
Objective: Assessment of fear extinction learning and memory in SNI and control mice using contextual fear conditioning to evaluate hippocampal-dependent behavior
Protocol Steps
1
Contextual Fear Conditioning and Extinction Assessment
SNI and Sham control mice were assessed for their ability to extinguish contextual fear. The study evaluated whether SNI animals could extinguish contextual fear compared to control animals.
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Note: SNI animals were unable to extinguish contextual fear, showing impaired extinction learning
View evidence from paper
“SNI animals were unable to extinguish contextual fear and showed increased anxiety-like behavior”