Contextual Fear Extinction Task
Objective: Assessment of fear extinction learning and memory in SNI and control mice using contextual fear conditioning to evaluate hippocampal-dependent behavior
This is a Contextual Fear Extinction Task protocol using mouse as the model organism. The procedure involves 1 procedural steps. Extracted from a 2012 paper published in Journal of Neuroscience.
Model and subjects
mouse • Not specified in provided text • unknown • Not specified in provided text • Not specified in provided text
Study window
Estimated timing pending
Core workflow
Contextual Fear Conditioning and Extinction Assessment
Primary readouts
- Contextual fear extinction ability
- Anxiety-like behavior
- Hippocampal extracellular signal-regulated kinase expression and phosphorylation
- Neurogenesis in hippocampus
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Contextual Fear Conditioning and Extinction Assessment
SNI and Sham control mice were assessed for their ability to extinguish contextual fear. The study evaluated whether SNI animals could extinguish contextual fear compared to control animals.
Note: SNI animals were unable to extinguish contextual fear, showing impaired extinction learning
View evidence from paper
“SNI animals were unable to extinguish contextual fear and showed increased anxiety-like behavior”