Source Paper
Functional assessments in the rodent stroke model
Krystal L Schaar, Miranda M Brenneman, Sean I Savitz
Experimental & Translational Stroke Medicine • 2010
View Abstract
Abstract Stroke is a common cause of permanent disability accompanied by devastating impairments for which there is a pressing need for effective treatment. Motor, sensory and cognitive deficits are common following stroke, yet treatment is limited. Along with histological measures, functional outcome in animal models has provided valuable insight to the biological basis and potential rehabilitation efforts of experimental stroke. Developing and using tests that have the ability to identify behavioral deficits is essential to expanding the development of translational therapies. The present aim of this paper is to review many of the current behavioral tests that assess functional outcome after stoke in rodent models. While there is no perfect test, there are many assessments that are sensitive to detecting the array of impairments, from global to modality specific, after stroke.
Corner Test
Objective: Assesses sensorimotor and postural asymmetries in rodents, particularly following unilateral brain damage such as stroke
This is a Corner Test protocol using rodent (rat or mouse) as the model organism. The procedure involves 3 procedural steps, 1 equipment items. Extracted from a 2010 paper published in Experimental & Translational Stroke Medicine.
Model and subjects
rodent (rat or mouse) • not specified • unknown • not specified • not specified
Study window
~20 minutes hands-on
Core workflow
Animal placement in corner apparatus • Conduct trials • Observe and record asymmetries
Primary readouts
- Sensorimotor asymmetries
- Postural asymmetries
- Detection of unilateral brain damage effects
Key equipment and reagents
Verified items
0
Direct vendor links
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Protocol Steps
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Animal placement in corner apparatus
Place the rodent in the corner apparatus for assessment
Note: No pre-training is required for this test
View evidence from paper
“Corner Test None 10 trials 5-10 minutes”
Conduct trials
Conduct 10 trials to assess sensorimotor and postural asymmetries
Note: The test involves 10 trials per session
View evidence from paper
“Corner Test None 10 trials 5-10 minutes”
Observe and record asymmetries
Observe the animal's behavior in the corner apparatus and record sensorimotor and postural asymmetries
Note: Tests of asymmetry help factor out confounding variables such as overall decrease in activity after surgical induction of stroke
View evidence from paper
“Tests of asymmetry help factor out confounding variables such as overall decrease in activity after surgical induction of stroke”