Source Paper
Mice Lacking the ERK1 Isoform of MAP Kinase Are Unimpaired in Emotional Learning
Joel C. Selcher, Tanya Nekrasova, Richard Paylor, Gary E. Landreth, J. David Sweatt
Learning & Memory • 2001
Cue Fear Conditioning
behavioralmouseNot specified in provided text
Objective: Measurement of acquisition and retention of fear memory to an auditory cue at 24 hours and 2 weeks post-training in mice
Protocol Steps
1
Cue Fear Conditioning Training
Mice underwent cue fear conditioning training to establish fear memory to an auditory cue
Not specified in provided textNot specified in provided text
Note: Training involved pairing an auditory cue with an unconditioned stimulus
View evidence from paper
“no differences were observed in the acquisition or retention (24 h and 2 wk after training) of either contextual or cue fear conditioning”
2
24-Hour Retention Test
Assessment of fear memory retention to the auditory cue at 24 hours post-training
24 hours after trainingNot specified in provided text
Note: Retention was measured in both ERK1-null and wild-type littermate controls
View evidence from paper
“no differences were observed in the acquisition or retention (24 h and 2 wk after training) of either contextual or cue fear conditioning”
3
2-Week Retention Test
Assessment of fear memory retention to the auditory cue at 2 weeks post-training
2 weeks after trainingNot specified in provided text
Note: Long-term retention was measured in both ERK1-null and wild-type littermate controls
View evidence from paper
“no differences were observed in the acquisition or retention (24 h and 2 wk after training) of either contextual or cue fear conditioning”