Cued Fear Conditioning
Objective: Assessment of cued fear conditioning as a control for non-hippocampal dependent learning to evaluate whether hippocampal neurogenesis ablation impairs cued conditioning
This is a Cued Fear Conditioning protocol using mouse as the model organism. The procedure involves 1 procedural steps. Extracted from a 2006 paper published in Proceedings of the National Academy of Sciences.
Model and subjects
mouse • Not specified in provided text • Not specified in provided text • Not specified in provided text • Not specified in provided text • Not specified in provided text
Study window
Estimated timing pending
Core workflow
Cued Fear Conditioning Assessment
Primary readouts
- Cued fear conditioning performance (freezing response to cue)
- Comparison between ablated and control animals
- Demonstration that cued conditioning is preserved despite hippocampal neurogenesis ablation
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Cued Fear Conditioning Assessment
Conduct cued fear conditioning as a behavioral control task to assess non-hippocampal dependent learning in animals with ablated hippocampal neurogenesis
Note: This task serves as a control to demonstrate that the behavioral deficits observed are specific to hippocampal-dependent learning and not due to general learning impairments
View evidence from paper
“focal X irradiation of the hippocampus or genetic ablation of glial fibrillary acidic protein-positive neural progenitor cells impaired contextual fear conditioning but not cued conditioning”