Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus

Michael D. Saxe, Fortunato Battaglia, Jing-Wen Wang, Gael Malleret, Denis J. David et al.

Proceedings of the National Academy of Sciences • 2006

DOI PMC

Cued Fear Conditioning

behavioralmouseNot specified in provided text

Objective: Assessment of cued fear conditioning as a control for non-hippocampal dependent learning to evaluate whether hippocampal neurogenesis ablation impairs cued conditioning

Protocol Steps

Cued Fear Conditioning Assessment

Conduct cued fear conditioning as a behavioral control task to assess non-hippocampal dependent learning in animals with ablated hippocampal neurogenesis

Not specified in provided textNot specified in provided text

Note: This task serves as a control to demonstrate that the behavioral deficits observed are specific to hippocampal-dependent learning and not due to general learning impairments

View evidence from paper

“focal X irradiation of the hippocampus or genetic ablation of glial fibrillary acidic protein-positive neural progenitor cells impaired contextual fear conditioning but not cued conditioning”