D-Cycloserine Rescue Experiment
Objective: To assess whether administration of d-cycloserine, an NMDA receptor partial coagonist, can rescue the increased repetitive grooming phenotype in adult NL1 knockout mice
This is a D-Cycloserine Rescue Experiment protocol using mouse as the model organism. The procedure involves 2 procedural steps, 1 materials. Extracted from a 2010 paper published in Journal of Neuroscience.
Model and subjects
mouse • NL1 knockout mice (specific strain not detailed in provided text) • unknown • adult • not specified
Study window
Estimated timing pending
Core workflow
Administer d-cycloserine to adult NL1 KO mice • Assess repetitive grooming behavior
Primary readouts
- Repetitive grooming behavior frequency and duration
- Rescue of increased grooming phenotype following d-cycloserine administration
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Administer d-cycloserine to adult NL1 KO mice
Administer the NMDA receptor partial coagonist d-cycloserine to adult mice to assess rescue of repetitive grooming phenotype
Note: Specific dosage, route of administration, and treatment schedule not detailed in provided text
View evidence from paper
“the increased repetitive grooming phenotype can be rescued in adult mice by administration of the NMDA receptor partial coagonist d-cycloserine”
Assess repetitive grooming behavior
Measure repetitive, stereotyped grooming behavior in treated mice to determine if d-cycloserine rescues the phenotype
Note: Specific behavioral testing methodology not detailed in provided text
View evidence from paper
“NL1 KO mice exhibit a dramatic increase in repetitive, stereotyped grooming behavior”