D-Cycloserine Rescue Experiment
Objective: To assess whether administration of d-cycloserine, an NMDA receptor partial coagonist, can rescue the increased repetitive grooming phenotype in adult NL1 knockout mice
Gather these items before starting the experiment. Check off items as you prepare.
Materials1
not specified • not applicable • not mentioned • not mentioned
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Protocol Steps
Administer d-cycloserine to adult NL1 KO mice
Administer the NMDA receptor partial coagonist d-cycloserine to adult mice to assess rescue of repetitive grooming phenotype
Note: Specific dosage, route of administration, and treatment schedule not detailed in provided text
View evidence from paper
“the increased repetitive grooming phenotype can be rescued in adult mice by administration of the NMDA receptor partial coagonist d-cycloserine”
Assess repetitive grooming behavior
Measure repetitive, stereotyped grooming behavior in treated mice to determine if d-cycloserine rescues the phenotype
Note: Specific behavioral testing methodology not detailed in provided text
View evidence from paper
“NL1 KO mice exhibit a dramatic increase in repetitive, stereotyped grooming behavior”