Source Paper
Hyperactivity and Intact Hippocampus-Dependent Learning in Mice Lacking the M<sub>1</sub>Muscarinic Acetylcholine Receptor
Tsuyoshi Miyakawa, Masahisa Yamada, Alokesh Duttaroy, Jürgen Wess
Journal of Neuroscience • 2001
Eight-Arm Radial Maze
Objective: Assessment of working memory and spatial learning using an eight-arm radial maze
This is a Eight-Arm Radial Maze protocol using mouse as the model organism. The procedure involves 1 procedural steps, 1 equipment items. Extracted from a 2001 paper published in Journal of Neuroscience.
Model and subjects
mouse • Not specified in provided text • unknown • Not specified in provided text • Not specified in provided text
Study window
Estimated timing pending
Core workflow
Eight-arm radial maze testing
Primary readouts
- Working memory performance
- Spatial learning ability
- Performance deficits in maze task
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Eight-arm radial maze testing
Mice were subjected to testing in an eight-arm radial maze to assess working memory and spatial learning performance
Note: M1R−/− mice showed slight performance deficits, most likely because of the hyperactivity phenotype displayed by the M1R−/− mice
View evidence from paper
“M1R−/− mice showed slight performance deficits in auditory-cued fear conditioning and in an eight-arm radial maze, most likely because of the hyperactivity phenotype”