Elevated Plus-Maze
Objective: Assessment of anxiety-like behavior using an elevated plus-maze test to measure locomotor activity and anxiogenic behavior in transgenic mice
This is a Elevated Plus-Maze protocol using mouse as the model organism. The procedure involves 2 procedural steps, 1 equipment items. Extracted from a 1994 paper published in Journal of Neuroscience.
Model and subjects
mouse • CRF transgenic mice and normal littermate controls • unknown • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Elevated Plus-Maze Testing • Measurement of Anxiogenic Behavior
Primary readouts
- Locomotor activity in novel environment
- Anxiety-like behavior on elevated plus-maze
- Anxiogenic behavior comparison between transgenic and control animals
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Elevated Plus-Maze Testing
CRF transgenic mice and normal littermate controls were tested using an elevated plus-maze to measure anxiety-like behavior and locomotor activity
Note: The elevated plus-maze served as an index of anxiety in the animals
View evidence from paper
“CRF transgenic mice and normal littermate controls were tested by measuring locomotor activity in a novel environment and through the use of an elevated plus-maze as indices of anxiety”
Measurement of Anxiogenic Behavior
Anxiogenic behavior was measured and compared between CRF transgenic animals and control littermates
Note: CRF transgenic animals exhibited an increase in anxiogenic behavior
View evidence from paper
“CRF transgenic animals exhibited an increase in anxiogenic behavior, an effect known to occur following central administration of CRF in mice and rats”