Source Paper
Prenatal and early postnatal cannabis exposure interactions with adolescent chronic stress on anxiety-like, depression-like, and risk-taking behaviour.
Peterson CS, Ifionu I, Hamood F, Semizeh H, Ali A et al.
Psychopharmacology (Berl) • 2026
Elevated Plus Maze
behavioralmouse
Objective: Measures anxiety-like behavior in mice
Materials & Equipment Checklist
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Protocol Steps
1
Prenatal and postnatal THC exposure
Mouse dams orally consume THC in whole cannabis oil daily
From GD1-PD10
Note: Dose: 5 mg/kg
View evidence from paper
“Mouse dams orally consumed 5 mg/kg THC in whole cannabis oil daily from GD1-PD10”
2
Chronic mild unpredictable stress exposure
Offspring are exposed to chronic mild unpredictable stress throughout adolescence
PD28-56
View evidence from paper
“Offspring were exposed to chronic mild unpredictable stress throughout adolescence (PD28-56)”
3
Elevated plus maze testing
Mice are challenged with elevated plus maze as part of behavioral battery to measure anxiety-like behavior
Note: Testing begins from PD58 as part of battery including other behavioral tests
View evidence from paper
“From PD58, mice were challenged with a battery of tests to measure anxiety-like (elevated plus maze”