Source Paper
Osteoclast‐Derived SLIT3 Mediates Osteoarthritis Pain and Degenerative Changes
Zhu W, Qin W, Gao J, Guo Y, Han X et al.
Adv Sci (Weinh) • 2025
Elevated Plus Maze Test
Objective: To assess anxiety-like behavior and depressive behavior in mice with TMJ-OA
This is a Elevated Plus Maze Test protocol using mice as the model organism. The procedure involves 3 procedural steps. Extracted from a 2025 paper published in Adv Sci (Weinh).
Model and subjects
mice • not specified • not specified • not specified • 6
Study window
Estimated timing pending
Core workflow
Behavioral assessment using elevated plus maze • Quantify open arm entries • Measure time in open arms
Primary readouts
- Number of entries into open arms
- Duration spent in open arms
Key equipment and reagents
Verified items
0
Direct vendor links
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Protocol Steps
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Behavioral assessment using elevated plus maze
Mice were tested using elevated plus maze test to measure anxiety-like behavior by recording entries into open arms and time spent in open arms
View evidence from paper
“elevated plus maze test (EPM)”
Quantify open arm entries
Count the number of entries into the open arms of the elevated plus maze
View evidence from paper
“fewer entries into the open arms”
Measure time in open arms
Record the duration spent in the open arms of the elevated plus maze
View evidence from paper
“shorter durations spent there in EPM”