Source Paper
Hyperactivity and Intact Hippocampus-Dependent Learning in Mice Lacking the M<sub>1</sub>Muscarinic Acetylcholine Receptor
Tsuyoshi Miyakawa, Masahisa Yamada, Alokesh Duttaroy, Jürgen Wess
Journal of Neuroscience • 2001
Elevated Plus Maze
Objective: Evaluation of anxiety-like behavior and locomotor activity using an elevated plus maze apparatus
This is a Elevated Plus Maze protocol using mouse as the model organism. The procedure involves 1 procedural steps, 1 equipment items. Extracted from a 2001 paper published in Journal of Neuroscience.
Model and subjects
mouse • M1 receptor-deficient mice (M1R−/− mice) and controls • unknown • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Elevated Plus Maze Test
Primary readouts
- Locomotor activity in elevated plus maze
- Anxiety-like behavior
- Time spent in open vs closed arms (implied from anxiety assessment)
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Elevated Plus Maze Test
Mice were subjected to the elevated plus maze test as part of a battery of behavioral tests to assess anxiety-like behavior and locomotor activity
Note: This test was one of several behavioral tests used to evaluate M1R−/− mice phenotype
View evidence from paper
“M1R−/− mice consistently exhibited a pronounced increase in locomotor activity in various tests, including open field, elevated plus maze, and light/dark transition tests”