Source Paper
Dopamine D4 Receptor-Knock-Out Mice Exhibit Reduced Exploration of Novel Stimuli
Stephanie C. Dulawa, David K. Grandy, Malcolm J. Low, Martin P. Paulus, Mark A. Geyer
Journal of Neuroscience • 1999
Emergence Test
Objective: Evaluation of approach-avoidance conflict behavior in mice emerging into a novel environment to assess novelty-seeking responses and exploratory behavior
This is a Emergence Test protocol using mouse as the model organism. The procedure involves 2 procedural steps, 1 equipment items. Extracted from a 1999 paper published in Journal of Neuroscience.
Model and subjects
mouse • D4R-knock-out (D4R−/−) and wild-type (D4R+/+) • unknown • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Subject Selection and Grouping • Emergence Test Execution
Primary readouts
- Behavioral responsiveness to novelty
- Exploratory behavior in response to novel environment
- Approach-avoidance conflict responses
- Novelty-seeking behavior
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Subject Selection and Grouping
D4R-knock-out (D4R−/−) and wild-type (D4R+/+) mice were selected for testing in the emergence paradigm as part of three approach-avoidance tests
Note: The emergence test was one of three paradigms used to evaluate behavioral responses to novelty
View evidence from paper
“we evaluated D4R-knock-out (D4R−/−) and wild-type (D4R+/+) mice in three approach–avoidance paradigms: the open field, emergence, and novel object tests”
Emergence Test Execution
Mice were tested in the emergence paradigm to measure approach-avoidance conflict behavior in response to novel stimuli
Note: The emergence test was designed to elicit approach or exploratory behavior and avoidance or anxiety-related behavior to varying degrees
View evidence from paper
“These three paradigms differ in the degree to which they elicit approach, or exploratory behavior, and avoidance, or anxiety-related behavior”