Emotional Behavior Testing
Objective: Evaluation of emotional alterations and responses in BACE1 null mice to assess emotional function and behavioral changes
This is a Emotional Behavior Testing protocol using mouse as the model organism. The procedure involves 2 procedural steps. Extracted from a 2005 paper published in Journal of Neuroscience.
Model and subjects
mouse • BACE1 null mice • unknown • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Emotional behavior testing • Comparative analysis
Primary readouts
- Emotional alterations in BACE1 null mice
- Performance on tests of emotion
- Comparison of emotional responses between BACE1 null and control mice
Key equipment and reagents
Verified items
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Direct vendor links
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Protocol Steps
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Emotional behavior testing
Conduct tests of emotion in BACE1 null mice to evaluate emotional alterations and responses
Note: The text indicates that BACE1 null mice manifest alterations in performance on tests of emotion, and that emotional alterations in BACE1 -/- mice are not prevented by coexpressing APPswe;PS1 ΔE9 transgenes
View evidence from paper
“BACE1 null mice manifest alterations in hippocampal synaptic plasticity as well as in performance on tests of cognition and emotion”
Comparative analysis
Compare emotional test performance between BACE1 null mice and control groups, including APPswe;PS1 ΔE9 transgenic mice
Note: Memory deficits but not emotional alterations in BACE1 -/- mice are prevented by coexpressing APPswe;PS1 ΔE9 transgenes, suggesting different neural circuits are involved
View evidence from paper
“memory deficits but not emotional alterations in BACE1 –/– mice are prevented by coexpressing APPswe;PS1 ΔE9 transgenes”