BACE1, a Major Determinant of Selective Vulnerability of the Brain to Amyloid-β Amyloidogenesis, is Essential for Cognitive, Emotional, and Synaptic Functions

Fiona M. Laird, Huaibin Cai, Alena V. Savonenko, Mohamed H. Farah, Kaiwen He et al.

Journal of Neuroscience • 2005

DOI PMC

Emotional Behavior Testing

behavioralmouseBACE1 null mice

Objective: Evaluation of emotional alterations and responses in BACE1 null mice to assess emotional function and behavioral changes

Protocol Steps

Emotional behavior testing

Conduct tests of emotion in BACE1 null mice to evaluate emotional alterations and responses

Not specifiedNot specified

Note: The text indicates that BACE1 null mice manifest alterations in performance on tests of emotion, and that emotional alterations in BACE1 -/- mice are not prevented by coexpressing APPswe;PS1 ΔE9 transgenes

View evidence from paper

“BACE1 null mice manifest alterations in hippocampal synaptic plasticity as well as in performance on tests of cognition and emotion”

Comparative analysis

Compare emotional test performance between BACE1 null mice and control groups, including APPswe;PS1 ΔE9 transgenic mice

Not specifiedNot specified

Note: Memory deficits but not emotional alterations in BACE1 -/- mice are prevented by coexpressing APPswe;PS1 ΔE9 transgenes, suggesting different neural circuits are involved

View evidence from paper

“memory deficits but not emotional alterations in BACE1 –/– mice are prevented by coexpressing APPswe;PS1 ΔE9 transgenes”