Fear Conditioning
Objective: Assessment of cue and context fear conditioning in ASIC1-null mice to test amygdala-dependent fear learning and determine the role of ASIC1 in fear conditioning behavior
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Equipment1
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Protocol Steps
Cue fear conditioning
ASIC1-null mice were subjected to cue fear conditioning to assess amygdala-dependent fear learning
Note: This is a standard fear conditioning paradigm testing associative learning between a cue and an aversive stimulus
View evidence from paper
“ASIC1-null mice displayed deficits in cue and context fear conditioning”
Context fear conditioning
ASIC1-null mice were subjected to context fear conditioning to assess amygdala-dependent fear learning
Note: This is a standard fear conditioning paradigm testing associative learning between environmental context and an aversive stimulus
View evidence from paper
“ASIC1-null mice displayed deficits in cue and context fear conditioning”
Baseline fear assessment
Baseline fear behavior was assessed in ASIC1-null mice using the elevated plus maze
Note: Baseline fear was found to be intact in ASIC1-null mice despite deficits in fear conditioning
View evidence from paper
“baseline fear on the elevated plus maze was intact”