Source Paper
Mice Lacking Metabotropic Glutamate Receptor 5 Show Impaired Learning and Reduced CA1 Long-Term Potentiation (LTP) But Normal CA3 LTP
You-Ming Lu, Zhengping Jia, Christopher Janus, Jeffrey T. Henderson, Robert Gerlai et al.
Journal of Neuroscience • 1997
Fear Conditioning Test
Objective: Assessment of contextual information acquisition and memory in mGluR5 mutant mice using fear conditioning
This is a Fear Conditioning Test protocol using mouse as the model organism. The procedure involves 1 procedural steps. Extracted from a 1997 paper published in Journal of Neuroscience.
Model and subjects
mouse • mGluR5 mutant mice • unknown • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Fear Conditioning Test
Primary readouts
- Acquisition of contextual information
- Memory for contextual information
- Comparison of performance between wild-type and mGluR5 mutant mice
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Fear Conditioning Test
Mice were tested for contextual information acquisition and memory using a fear-conditioning test
Note: The test was used to assess whether mGluR5 mutant mice were impaired in the acquisition and use of contextual information
View evidence from paper
“These mutant mice were also impaired in the acquisition and use of spatial information in both the Morris water maze and contextual information in the fear-conditioning test.”