Source Paper
Atrophin-1 antisense oligonucleotide provides robust protection from pathology in a fully humanized DRPLA model
Smith VL, Gidi BZ, Bragg RM, Cantle JP, Ben-Varon A et al.
Mol Ther Nucleic Acids • 2025
Fixed Rotarod Test
Objective: Motor coordination assessment using a fixed rotarod apparatus
This is a Fixed Rotarod Test protocol using Mouse as the model organism. The procedure involves 3 procedural steps, 1 equipment items. Extracted from a 2025 paper published in Mol Ther Nucleic Acids.
Model and subjects
Mouse • Not specified • Male and female • 6 to 7 weeks • Not specified
Study window
Estimated timing pending
Core workflow
Training phase • Testing phase • Age requirement
Primary readouts
- Time spent on rotarod during trials
- Motor coordination performance
Key equipment and reagents
Verified items
0
Direct vendor links
0
Use this page as an execution guide, then fall back to the source paper whenever you need exact exclusions, dosing details, or assay-specific caveats.
Confirm first
- Verify the animal model, intervention setup, and collection timepoints against the source paper.
- Check that every direct vendor link matches the exact specification your lab plans to run.
Use the page like this
- Work through the protocol steps in order and use the inline vendor chips only when you need to source or verify an item.
- Jump to Experimental Context for readouts, data shape, and analysis flow before planning downstream analysis.
Protocol Steps
Start here. The step list is optimized for running the experiment, with direct vendor links available inline when you need to source a cited item.
Training phase
Conduct three 5-minute training trials at two different speeds
View evidence from paper
“Each mouse went through three 5-min training trials at two speeds (4 and 8 rpm)”
Testing phase
Test mice for three trials at both speeds with maximum time limit
View evidence from paper
“Mice were then tested for three trials at both speeds with a maximum time of 5 min”
Age requirement
Perform training and testing during specific age window
View evidence from paper
“All mice were tested and trained from 6 to 7 weeks of age”