Source Paper
Atrophin-1 antisense oligonucleotide provides robust protection from pathology in a fully humanized DRPLA model
Smith VL, Gidi BZ, Bragg RM, Cantle JP, Ben-Varon A et al.
Mol Ther Nucleic Acids • 2025
Fixed Rotarod Test
behavioralMouseNot specified
Objective: Motor coordination assessment using a fixed rotarod apparatus
Materials & Equipment Checklist
1 item1 from ConductScience
Gather these items before starting the experiment. Check off items as you prepare.
Equipment1
Harvard Apparatus, 76-0770
1 item available from ConductScience
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Protocol Steps
1
Training phase
Conduct three 5-minute training trials at two different speeds
View evidence from paper
“Each mouse went through three 5-min training trials at two speeds (4 and 8 rpm)”
2
Testing phase
Test mice for three trials at both speeds with maximum time limit
View evidence from paper
“Mice were then tested for three trials at both speeds with a maximum time of 5 min”
3
Age requirement
Perform training and testing during specific age window
View evidence from paper
“All mice were tested and trained from 6 to 7 weeks of age”