Forced Swim Test
Objective: To induce aversive behaviors in mice through repeated forced swim stress and measure dysphoric responses
This is a Forced Swim Test protocol using mouse as the model organism. The procedure involves 2 procedural steps, 1 equipment items. Extracted from a 2008 paper published in Journal of Neuroscience.
Model and subjects
mouse • Not explicitly stated in provided text • unknown • Not explicitly stated in provided text • Not explicitly stated in provided text
Study window
Estimated timing pending
Core workflow
Repeated forced swim stress • Measure aversive behavioral responses
Primary readouts
- Aversive behaviors induced by forced swim stress
- Blockade of aversive responses by κ-opioid receptor antagonist
- Presence or absence of aversive behaviors in dynorphin-deficient mice
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Repeated forced swim stress
Mice were subjected to repeated forced swim stress as a form of stress presumed to evoke dysphoria
Note: This stress paradigm was used to produce aversive behaviors in mice
View evidence from paper
“repeated forced swim and inescapable footshock both produced aversive behaviors that were blocked by a κ-opioid receptor antagonist”
Measure aversive behavioral responses
Assess aversive behaviors produced by the forced swim stress
Note: Aversive behaviors were blocked by κ-opioid receptor antagonist and absent in dynorphin-deficient mice
View evidence from paper
“repeated forced swim and inescapable footshock both produced aversive behaviors that were blocked by a κ-opioid receptor (KOR) antagonist and absent in mice lacking dynorphin”