Forced Swim Test
behavioralmouseTransgenic mice overexpressing glycogen synthase kinase 3β
Objective: Assessment of immobility and depressive-like behavior in a forced swim paradigm, with particular focus on measuring reduced immobility in transgenic mice
Materials & Equipment Checklist
1 item1 from ConductScience
Gather these items before starting the experiment. Check off items as you prepare.
Equipment1
Not specified • Not specified • Not specified • Not specified
1 item available from ConductScience
As an Amazon Associate, we earn from qualifying purchases. Product links help support this free resource.
Protocol Steps
1
Conduct forced swim test
Transgenic mice and control animals were subjected to the forced swim test to measure immobility as an indicator of depressive-like behavior
Not specifiedNot specified
Note: Reduced immobility was observed in transgenic mice, though this was attributed to their hyperactivity phenotype rather than antidepressant-like effects
View evidence from paper
“The forced swim test revealed a reduced immobility in transgenic mice, but this is probably related to the hyperactivity of the animals.”