Forced Swim Test
Objective: Assessment of immobility and depressive-like behavior in a forced swim paradigm, with particular focus on measuring reduced immobility in transgenic mice
This is a Forced Swim Test protocol using mouse as the model organism. The procedure involves 1 procedural steps, 1 equipment items. Extracted from a 2006 paper published in Journal of Neuroscience.
Model and subjects
mouse • Transgenic mice overexpressing glycogen synthase kinase 3β • unknown • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Conduct forced swim test
Primary readouts
- Immobility duration/frequency
- Depressive-like behavior assessment
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Conduct forced swim test
Transgenic mice and control animals were subjected to the forced swim test to measure immobility as an indicator of depressive-like behavior
Note: Reduced immobility was observed in transgenic mice, though this was attributed to their hyperactivity phenotype rather than antidepressant-like effects
View evidence from paper
“The forced swim test revealed a reduced immobility in transgenic mice, but this is probably related to the hyperactivity of the animals.”