Source Paper
Essential role of brain-derived neurotrophic factor in adult hippocampal function
Lisa M. Monteggia, Michel Barrot, Craig M. Powell, Olivier Berton, Victor Galanis et al.
Proceedings of the National Academy of Sciences • 2004
Forced Swim Test
Objective: Assessment of antidepressant efficacy of desipramine and the role of forebrain BDNF in antidepressant response using the forced swim test
This is a Forced Swim Test protocol using mouse as the model organism. The procedure involves 1 procedural steps, 1 equipment items, 1 materials. Extracted from a 2004 paper published in Proceedings of the National Academy of Sciences.
Model and subjects
mouse • Not specified in provided text • unknown • Not specified in provided text • Not specified in provided text
Study window
Estimated timing pending
Core workflow
Forced swim test administration
Primary readouts
- Antidepressant efficacy of desipramine
- Behavioral response in forced swim test
- Effect of forebrain BDNF deletion on antidepressant response
Key equipment and reagents
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Protocol Steps
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Forced swim test administration
Conduct forced swim test to assess antidepressant efficacy of desipramine in mice with and without forebrain BDNF deletion
Note: Test was used to demonstrate that loss of forebrain BDNF attenuates antidepressant actions
View evidence from paper
“the loss of forebrain BDNF attenuates the actions of desipramine, an antidepressant, in the forced swim test”