Source Paper
Essential role of brain-derived neurotrophic factor in adult hippocampal function
Lisa M. Monteggia, Michel Barrot, Craig M. Powell, Olivier Berton, Victor Galanis et al.
Proceedings of the National Academy of Sciences • 2004
Forced Swim Test
Objective: Assessment of antidepressant efficacy of desipramine and the role of forebrain BDNF in antidepressant response using the forced swim test
Gather these items before starting the experiment. Check off items as you prepare.
Equipment1
Not specified in provided text • Not specified in provided text • Not specified in provided text • Not specified in provided text
Materials1
Not specified in provided text • Not specified in provided text • Not specified in provided text • Not specified in provided text
1 item available from ConductScience
As an Amazon Associate, we earn from qualifying purchases. Product links help support this free resource.
Protocol Steps
Forced swim test administration
Conduct forced swim test to assess antidepressant efficacy of desipramine in mice with and without forebrain BDNF deletion
Note: Test was used to demonstrate that loss of forebrain BDNF attenuates antidepressant actions
View evidence from paper
“the loss of forebrain BDNF attenuates the actions of desipramine, an antidepressant, in the forced swim test”