Forced Swim Test
Objective: Measures helplessness and depressive-like behavior in mice after stress exposure
This is a Forced Swim Test protocol using mouse as the model organism. The procedure involves 2 procedural steps. Extracted from a 2005 paper published in Journal of Neuroscience.
Model and subjects
mouse • GR+/- (GR-heterozygous mutant mice) and GR overexpressing mice • unknown • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Stress Exposure • Forced Swim Test
Primary readouts
- Helplessness behavior
- Depressive-like behavior
- Stress-induced behavioral changes
Key equipment and reagents
Verified items
0
Direct vendor links
0
Use this page as an execution guide, then fall back to the source paper whenever you need exact exclusions, dosing details, or assay-specific caveats.
Confirm first
- Verify the animal model, intervention setup, and collection timepoints against the source paper.
- Check that every direct vendor link matches the exact specification your lab plans to run.
Use the page like this
- Work through the protocol steps in order and use the inline vendor chips only when you need to source or verify an item.
- Jump to Experimental Context for readouts, data shape, and analysis flow before planning downstream analysis.
Protocol Steps
Start here. The step list is optimized for running the experiment, with direct vendor links available inline when you need to source a cited item.
Stress Exposure
Mice are exposed to stress to induce depressive-like behavior
Note: Stress exposure precedes the forced swim test measurement
View evidence from paper
“GR+/- mice exhibit normal baseline behaviors but demonstrate increased helplessness after stress exposure, a behavioral correlate of depression in mice”
Forced Swim Test
Mice are tested in forced swim test to measure helplessness behavior following stress exposure
Note: Test measures behavioral correlate of depression through helplessness assessment
View evidence from paper
“GR+/- mice exhibit normal baseline behaviors but demonstrate increased helplessness after stress exposure, a behavioral correlate of depression in mice”