Source Paper
Serotonin receptor 1A knockout: An animal model of anxiety-related disorder
Sylvie Ramboz, Ronald Oosting, Djamel Aït Amara, Hank F. Kung, Pierre Blier et al.
Proceedings of the National Academy of Sciences • 1998
Forced Swim Test
Objective: Measurement of immobility behavior as an indicator of depressive-like phenotype in mice
This is a Forced Swim Test protocol using mouse as the model organism. The procedure involves 1 procedural steps, 1 equipment items. Extracted from a 1998 paper published in Proceedings of the National Academy of Sciences.
Model and subjects
mouse • 5-HT1A knockout mice and wild-type controls • Not specified • Not specified • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Conduct forced swim test
Primary readouts
- Immobility duration or frequency during forced swim test
- Comparison of immobility between 5-HT1A knockout mice, heterozygote mutants, and wild-type controls
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Conduct forced swim test
Mice were subjected to the forced swim test to measure immobility behavior as an indicator of depressive-like phenotype
Note: The test measures immobility, with decreased immobility being associated with antidepressant-like effects
View evidence from paper
“5-HT1A knockout mice also exhibited a decreased immobility in the forced swim test, an effect commonly associated with antidepressant treatment”