Gait Analysis
behavioralmouseWild-type and ASO (alpha-synuclein overexpressing)
Objective: Assessment of gait patterns and walking ability in mice, as part of a battery of sensorimotor tests sensitive to alterations in the nigrostriatal dopaminergic system
Protocol Steps
1
Testing schedule establishment
Male wild-type and ASO mice were tested for motor performance and coordination
Every 2 months for 8 months
Note: Testing included multiple sensorimotor assessments
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“Male wild-type and ASO mice were tested every 2 months for 8 months for motor performance and coordination”
2
Challenging beam test
Assessment of motor performance and coordination on a challenging beam
View evidence from paper
“motor performance and coordination on a challenging beam, inverted grid, and pole”
3
Inverted grid test
Assessment of motor performance and coordination on an inverted grid
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“motor performance and coordination on a challenging beam, inverted grid, and pole”
4
Pole test
Assessment of motor performance and coordination on a pole
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“motor performance and coordination on a challenging beam, inverted grid, and pole”
5
Adhesive removal test
Assessment of sensorimotor deficits using adhesive removal
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“sensorimotor deficits in an adhesive removal test”
6
Spontaneous activity in cylinder
Measurement of spontaneous activity levels in a cylinder
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“spontaneous activity in a cylinder, and gait”
7
Gait analysis
Assessment of gait patterns and walking ability
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“spontaneous activity in a cylinder, and gait”
8
Fine motor skills assessment
Assessment of fine motor skills by the ability to grasp cotton from a bin
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“Fine motor skills were assessed by the ability to grasp cotton from a bin”