Gait Analysis
Objective: Assessment of gait patterns and walking ability in mice, as part of a battery of sensorimotor tests sensitive to alterations in the nigrostriatal dopaminergic system
This is a Gait Analysis protocol using mouse as the model organism. The procedure involves 8 procedural steps, 4 equipment items. Extracted from a 2004 paper published in Journal of Neuroscience.
Model and subjects
mouse • Wild-type and ASO (alpha-synuclein overexpressing) • male • Tested every 2 months for 8 months, starting at 2 months of age
Study window
Estimated timing pending
Core workflow
Testing schedule establishment • Challenging beam test • Inverted grid test
Primary readouts
- Gait patterns and walking ability
- Motor performance and coordination
- Sensorimotor deficits
- Spontaneous activity levels
Key equipment and reagents
Use this page as an execution guide, then fall back to the source paper whenever you need exact exclusions, dosing details, or assay-specific caveats.
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- Verify the animal model, intervention setup, and collection timepoints against the source paper.
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- Jump to Experimental Context for readouts, data shape, and analysis flow before planning downstream analysis.
Protocol Steps
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Testing schedule establishment
Male wild-type and ASO mice were tested for motor performance and coordination
Note: Testing included multiple sensorimotor assessments
View evidence from paper
“Male wild-type and ASO mice were tested every 2 months for 8 months for motor performance and coordination”
Challenging beam test
Assessment of motor performance and coordination on a challenging beam
View evidence from paper
“motor performance and coordination on a challenging beam, inverted grid, and pole”
Inverted grid test
Assessment of motor performance and coordination on an inverted grid
View evidence from paper
“motor performance and coordination on a challenging beam, inverted grid, and pole”
Pole test
Assessment of motor performance and coordination on a pole
View evidence from paper
“motor performance and coordination on a challenging beam, inverted grid, and pole”
Adhesive removal test
Assessment of sensorimotor deficits using adhesive removal
View evidence from paper
“sensorimotor deficits in an adhesive removal test”
Spontaneous activity in cylinder
Measurement of spontaneous activity levels in a cylinder
View evidence from paper
“spontaneous activity in a cylinder, and gait”
Gait analysis
Assessment of gait patterns and walking ability
View evidence from paper
“spontaneous activity in a cylinder, and gait”
Fine motor skills assessment
Assessment of fine motor skills by the ability to grasp cotton from a bin
View evidence from paper
“Fine motor skills were assessed by the ability to grasp cotton from a bin”