Gait and Motor Function Testing
Objective: Analysis of gait and motor dysfunctions in Adnp+/- mice and evaluation of NAP treatment efficacy on motor function
This is a Gait and Motor Function Testing protocol using mouse as the model organism. The procedure involves 3 procedural steps, 1 materials. Extracted from a 2018 paper published in Journal of Clinical Investigation.
Model and subjects
mouse • Adnp+/- (haploinsufficient mutant line) • unknown • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Gait and Motor Function Assessment • NAP Treatment Administration • Post-Treatment Motor Function Evaluation
Primary readouts
- Gait dysfunction assessment
- Motor dysfunction evaluation
- Response to NAP treatment
- Developmental delay markers
Key equipment and reagents
Verified items
0
Direct vendor links
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Protocol Steps
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Gait and Motor Function Assessment
Evaluation of gait and motor dysfunctions in Adnp+/- mice
Note: Specific testing apparatus and methodology not detailed in provided text
View evidence from paper
“Adnp+/- mice further exhibited global developmental delays, vocalization impediments, gait and motor dysfunctions”
NAP Treatment Administration
Daily NAP administration via systemic or nasal routes
Note: Treatment was administered both systemically and nasally
View evidence from paper
“all of which were partially reversed by daily NAP administration (systemic/nasal)”
Post-Treatment Motor Function Evaluation
Re-assessment of gait and motor function following NAP treatment
Note: Motor dysfunctions were partially reversed by NAP treatment
View evidence from paper
“gait and motor dysfunctions, and social and object memory impairments, all of which were partially reversed by daily NAP administration”