Immediate Memory Task
Objective: Assessment of immediate memory function in mice with SIRT1 deficiency and overexpression to evaluate the role of SIRT1 in cognitive abilities
This is a Immediate Memory Task protocol using mouse as the model organism. The procedure involves 2 procedural steps. Extracted from a 2010 paper published in Journal of Neuroscience.
Model and subjects
mouse • Not specified in provided text • unknown • Not specified in provided text • Not specified in provided text
Study window
Estimated timing pending
Core workflow
Behavioral Assessment of Immediate Memory • Evaluation of Cognitive Deficits
Primary readouts
- Immediate memory performance in SIRT1-deficient mice
- Immediate memory performance in SIRT1-overexpressing mice
- Comparison of cognitive abilities between genotypes
Key equipment and reagents
Verified items
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Direct vendor links
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Protocol Steps
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Behavioral Assessment of Immediate Memory
Conducted behavioral paradigms to analyze effects of SIRT1 deficiency and overexpression on mouse immediate memory function
Note: Part of combination of behavioral and electrophysiological paradigms used to assess cognitive function
View evidence from paper
“Using a combination of behavioral and electrophysiological paradigms, we analyzed the effects of SIRT1 deficiency and overexpression on mouse learning and memory”
Evaluation of Cognitive Deficits
Demonstrated that absence of SIRT1 impaired cognitive abilities including immediate memory, classical conditioning, and spatial learning
Note: Specific behavioral tests used for immediate memory assessment not detailed in provided text
View evidence from paper
“We demonstrated that the absence of SIRT1 impaired cognitive abilities, including immediate memory, classical conditioning, and spatial learning”