Deficiency in Na,K-ATPase α Isoform Genes Alters Spatial Learning, Motor Activity, and Anxiety in Mice

Amy E. Moseley, Michael T. Williams, Tori L. Schaefer, Cynthia S. Bohanan, Jon C. Neumann et al.

Journal of Neuroscience • 2007

DOI PMC

Locomotor Activity Testing

behavioralmouseNot explicitly stated in provided text

Objective: Measurement of spontaneous motor activity and locomotor responses in mice, including baseline activity and response to methamphetamine stimulation

Protocol Steps

Locomotor Activity Assessment

Mice were tested for spontaneous motor activity and locomotor responses

Not explicitly statedNot explicitly stated

Note: The text indicates that locomotor activity was measured in heterozygous mice for different Na,K-ATPase α isoforms, with results showing reduced activity in α2 heterozygotes and increased activity in α3 heterozygotes

View evidence from paper

“Mice heterozygous for the α2 isoform display increased anxiety-related behavior, reduced locomotor activity, and impaired spatial learning”

Methamphetamine Response Testing

Mice were tested for locomotor response to methamphetamine administration

Not explicitly statedNot explicitly stated

Note: Both α3 and α1 heterozygous mice showed increased locomotor response to methamphetamine

View evidence from paper

“Mice heterozygous for the α3 isoform displayed spatial learning and memory deficits unrelated to differences in cued learning in the Morris maze, increased locomotor activity, an increased locomotor response to methamphetamine”