Locomotor Activity Testing
Objective: Measurement of spontaneous motor activity and locomotor responses in mice, including baseline activity and response to methamphetamine stimulation
This is a Locomotor Activity Testing protocol using mouse as the model organism. The procedure involves 2 procedural steps. Extracted from a 2007 paper published in Journal of Neuroscience.
Model and subjects
mouse • Not explicitly stated in provided text • unknown • Not explicitly stated in provided text • Not explicitly stated in provided text
Study window
Estimated timing pending
Core workflow
Locomotor Activity Assessment • Methamphetamine Response Testing
Primary readouts
- Spontaneous locomotor activity levels
- Locomotor response to methamphetamine
- Anxiety-related behavior
- Spatial learning performance
Key equipment and reagents
Verified items
0
Direct vendor links
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Protocol Steps
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Locomotor Activity Assessment
Mice were tested for spontaneous motor activity and locomotor responses
Note: The text indicates that locomotor activity was measured in heterozygous mice for different Na,K-ATPase α isoforms, with results showing reduced activity in α2 heterozygotes and increased activity in α3 heterozygotes
View evidence from paper
“Mice heterozygous for the α2 isoform display increased anxiety-related behavior, reduced locomotor activity, and impaired spatial learning”
Methamphetamine Response Testing
Mice were tested for locomotor response to methamphetamine administration
Note: Both α3 and α1 heterozygous mice showed increased locomotor response to methamphetamine
View evidence from paper
“Mice heterozygous for the α3 isoform displayed spatial learning and memory deficits unrelated to differences in cued learning in the Morris maze, increased locomotor activity, an increased locomotor response to methamphetamine”