Cocaine supersensitivity and enhanced motivation for reward in mice lacking dopamine D2 autoreceptors

Estefanía P Bello, Yolanda Mateo, Diego M Gelman, Daniela Noaín, Jung H Shin et al.

Nature Neuroscience • 2011

Locomotor Activity Testing

behavioralmouseautoDrd2KO (Drd2 loxP/loxP; Dat +/IRES-cre)

Objective: Measurement of spontaneous locomotor activity to assess hyperlocomotion in autoDrd2KO mice lacking dopamine D2 autoreceptors

Measurement of spontaneous locomotor activity in autoDrd2KO mice to assess hyperlocomotion phenotype

Not specifiedNot specified

Note: Specific apparatus details, testing duration, and environmental conditions are not provided in the extracted text

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“AutoDrd2KO mice displayed elevated DA synthesis and release, hyperlocomotion and supersensitivity to the psychomotor effects of cocaine”