Mechanical Allodynia Testing
Objective: Measurement of pain sensitivity using mechanical stimulation in astrocyte-specific trkB.T1 knockout mice after spinal cord injury to assess mechanical allodynia and hyperpathic responses
This is a Mechanical Allodynia Testing protocol using mouse as the model organism. The procedure involves 1 procedural steps, 1 equipment items. Extracted from a 2017 paper published in Journal of Neuroscience.
Model and subjects
mouse • astrocyte-specific trkB.T1 knockout mice • unknown • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Mechanical Allodynia Testing
Primary readouts
- Mechanical allodynia response
- Hyperpathic responses
- Pain-related measurements
- Motor coordination
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Mechanical Allodynia Testing
Conduct mechanical allodynia testing on astrocyte-specific trkB.T1 knockout mice after spinal cord injury using the CatWalk system to measure pain sensitivity and hyperpathic responses
Note: Testing was performed on both WT and KO mice to compare hyperpathic responses; KO mice showed reduced hyperpathic responses compared to WT controls
View evidence from paper
“using mechanical allodynia and pain-related measurements on the CatWalk, these animals also showed reduced hyperpathic responses, along with improved motor coordination”