Memory Persistence Assessment
Objective: Evaluation of long-term memory persistence and the effects of BDNF on transforming non-lasting memory traces into persistent ones
This is a Memory Persistence Assessment protocol using Not specified in provided text as the model organism. The procedure involves 3 procedural steps, 1 equipment items, 1 materials. Extracted from a 2008 paper published in Proceedings of the National Academy of Sciences.
Model and subjects
Not specified in provided text • Not specified in provided text • Not specified in provided text • Not specified in provided text • Not specified in provided text • Not specified in provided text
Study window
Estimated timing pending
Core workflow
Memory acquisition phase • Intrahippocampal BDNF delivery • Memory persistence assessment
Primary readouts
- Memory persistence duration
- Transformation of non-lasting memory traces into persistent ones
- Effects of BDNF on memory consolidation
- ERK-dependent signaling in memory persistence
Key equipment and reagents
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Protocol Steps
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Memory acquisition phase
Subjects undergo training or exposure to establish initial memory traces
Note: This phase establishes the baseline memory that will be tested for persistence
View evidence from paper
“Persistence is a characteristic attribute of long-term memories (LTMs)”
Intrahippocampal BDNF delivery
BDNF is delivered directly into the hippocampus to induce memory persistence
Note: BDNF induces memory persistence by transforming a nonlasting LTM trace into a persistent one in an ERK-dependent manner
View evidence from paper
“intrahippocampal delivery of BDNF reverses the deficit in memory persistence caused by inhibition of hippocampal protein synthesis”
Memory persistence assessment
Long-term memory persistence is evaluated at delayed time points post-acquisition
Note: Assessment determines whether memory traces persist or are forgotten
View evidence from paper
“we demonstrate that BDNF induces memory persistence by itself, transforming a nonlasting LTM trace into a persistent one”