Memory Persistence Assessment
Objective: Evaluation of long-term memory persistence and the effects of BDNF on transforming non-lasting memory traces into persistent ones
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Equipment1
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Materials1
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Protocol Steps
Memory acquisition phase
Subjects undergo training or exposure to establish initial memory traces
Note: This phase establishes the baseline memory that will be tested for persistence
View evidence from paper
“Persistence is a characteristic attribute of long-term memories (LTMs)”
Intrahippocampal BDNF delivery
BDNF is delivered directly into the hippocampus to induce memory persistence
Note: BDNF induces memory persistence by transforming a nonlasting LTM trace into a persistent one in an ERK-dependent manner
View evidence from paper
“intrahippocampal delivery of BDNF reverses the deficit in memory persistence caused by inhibition of hippocampal protein synthesis”
Memory persistence assessment
Long-term memory persistence is evaluated at delayed time points post-acquisition
Note: Assessment determines whether memory traces persist or are forgotten
View evidence from paper
“we demonstrate that BDNF induces memory persistence by itself, transforming a nonlasting LTM trace into a persistent one”