Memory Retention Testing
behavioralmouseAPPswe/PS1dE9
Objective: Assessment of stability and maintenance of newly consolidated contextual memories over a 2-week period in HDACi-treated transgenic mice
Materials & Equipment Checklist
3 items
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Protocol Steps
1
HDACi Treatment Administration
Chronic histone deacetylase inhibitor injections administered to transgenic mice
2-3 weeksNot specified
Note: Treatment with sodium valproate, sodium butyrate, or vorinostat
View evidence from paper
“Chronic HDACi injections (2–3 weeks) did not alter contextual memory formation in normal mice, but had profound effects in transgenic animals”
2
Memory Retention Assessment
Behavioral testing of HDACi-treated transgenic mice to assess stability and maintenance of newly consolidated contextual memories
2-week periodNot specified
Note: Testing conducted over 2-week period following HDACi treatment
View evidence from paper
“Further behavioral testing of the HDACi-treated transgenic mice showed that the newly consolidated memories were stably maintained over a 2-week period”