Memory Retention Testing
Objective: Assessment of stability and maintenance of newly consolidated contextual memories over a 2-week period in HDACi-treated transgenic mice
This is a Memory Retention Testing protocol using mouse as the model organism. The procedure involves 2 procedural steps, 3 materials. Extracted from a 2009 paper published in Neuropsychopharmacology.
Model and subjects
mouse • APPswe/PS1dE9 • Not specified • 6 months of age and older • Not specified • Not specified
Study window
~3 week study window
Core workflow
HDACi Treatment Administration • Memory Retention Assessment
Primary readouts
- Stability of newly consolidated contextual memories
- Maintenance of contextual memory over 2-week period
- Contextual memory performance in HDACi-treated transgenic mice
Key equipment and reagents
Use this page as an execution guide, then fall back to the source paper whenever you need exact exclusions, dosing details, or assay-specific caveats.
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- Verify the animal model, intervention setup, and collection timepoints against the source paper.
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Protocol Steps
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HDACi Treatment Administration
Chronic histone deacetylase inhibitor injections administered to transgenic mice
Note: Treatment with sodium valproate, sodium butyrate, or vorinostat
View evidence from paper
“Chronic HDACi injections (2–3 weeks) did not alter contextual memory formation in normal mice, but had profound effects in transgenic animals”
Memory Retention Assessment
Behavioral testing of HDACi-treated transgenic mice to assess stability and maintenance of newly consolidated contextual memories
Note: Testing conducted over 2-week period following HDACi treatment
View evidence from paper
“Further behavioral testing of the HDACi-treated transgenic mice showed that the newly consolidated memories were stably maintained over a 2-week period”