Morris Water Maze
Objective: Test of spatial learning and memory in which mice navigate to a hidden platform in a water-filled maze
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Protocol Steps
Morris water maze spatial learning test
Mice were tested in the Morris water maze to assess spatial learning and memory. The test involved navigation to a hidden platform in a water-filled maze.
Note: Test was used to measure spatial learning deficits in heterozygous mice for different Na,K-ATPase α isoforms
View evidence from paper
“mice heterozygous for the α2 isoform display increased anxiety-related behavior, reduced locomotor activity, and impaired spatial learning in the Morris water maze”
Cued learning assessment
Cued learning was assessed in the Morris maze to determine if spatial learning deficits were related to differences in cued learning ability.
Note: Used to differentiate between spatial learning deficits and general learning impairments
View evidence from paper
“Mice heterozygous for the α3 isoform displayed spatial learning and memory deficits unrelated to differences in cued learning in the Morris maze”