Morris Water Maze - Classic Version
Objective: Measure spatial memory for a fixed platform location in the Morris water maze to assess cognitive performance in enriched versus standard-housed mice, particularly in transgenic Alzheimer's disease models
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Protocol Steps
Housing Assignment
Female transgenic mice overexpressing amyloid precursor protein and/or presenilin-1 and nontransgenic controls were placed into enriched or standard cages at 2 months of age
Note: Mice were divided into enriched and standard housing conditions
View evidence from paper
“Female transgenic mice overexpressing amyloid precursor protein and/or presenilin-1 and nontransgenic controls were placed into enriched or standard cages at 2 months of age and tested for cognitive behavior after 6 months of differential housing.”
Classic Morris Water Maze Testing
Mice were tested in the classic Morris water maze to measure memory for a fixed platform location
Note: Performance measured for platform location memory; amyloid-β overproducing mice showed weaker memory compared to nontransgenic cagemates
View evidence from paper
“Mice overproducing amyloid-β (Aβ), particularly those with amyloid deposits, showed weaker memory for the platform location in the classic Morris water maze”
Repeated-Reversals Morris Water Maze Testing
Mice were tested in repeated-reversal versions of the Morris water maze to measure learning of new platform positions
Note: Amyloid-β overproducing mice learned new platform positions less quickly than nontransgenic cagemates
View evidence from paper
“learned new platform positions in the repeated-reversals task less quickly than their nontransgenic cagemates”