Source Paper
Plant-Derived Flavanol (−)Epicatechin Enhances Angiogenesis and Retention of Spatial Memory in Mice
Henriette van Praag, Melanie J. Lucero, Gene W. Yeo, Kimberly Stecker, Neema Heivand et al.
Journal of Neuroscience • 2007
Morris Water Maze
Objective: Assess retention of spatial memory in sedentary or wheel-running mice following epicatechin consumption using the Morris water maze
This is a Morris Water Maze protocol using mouse as the model organism. The procedure involves 1 procedural steps, 1 equipment items, 1 materials. Extracted from a 2007 paper published in Journal of Neuroscience.
Model and subjects
mouse • C57BL/6 • female • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Morris water maze testing
Primary readouts
- Retention of spatial memory
- Angiogenesis in dentate gyrus of hippocampus
- Neuronal spine density in dentate gyrus of hippocampus
- Newborn cell survival in dentate gyrus of hippocampus
Key equipment and reagents
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Protocol Steps
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Morris water maze testing
Mice were tested in the Morris water maze to assess retention of spatial memory
Note: Testing was conducted in both sedentary and wheel-running mice that received epicatechin consumption
View evidence from paper
“Retention of spatial memory in the water maze was enhanced by ingestion of (−)epicatechin, especially in combination with exercise”