Source Paper
Requirement for Hippocampal CA3 NMDA Receptors in Associative Memory Recall
Kazu Nakazawa, Michael C. Quirk, Raymond A. Chitwood, Masahiko Watanabe, Mark F. Yeckel et al.
Science • 2002
Morris Water Maze
Objective: Assess spatial reference memory acquisition and retrieval in mutant mice under full and partial cue conditions to test CA3 NMDA receptor involvement in associative memory recall
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Equipment1
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Protocol Steps
Spatial Reference Memory Acquisition
Mutant mice were trained to acquire spatial reference memory in the Morris water maze under standard conditions
Note: Normal acquisition observed in mutant mice
View evidence from paper
“mutant mice normally acquired and retrieved spatial reference memory in the Morris water maze”
Full Cue Retrieval Testing
Mice were tested for memory retrieval with all original environmental cues present
Note: Normal retrieval performance observed in mutant mice with full cues
View evidence from paper
“mutant mice normally acquired and retrieved spatial reference memory in the Morris water maze”
Partial Cue Retrieval Testing
Mice were tested for memory retrieval when presented with only a fraction of the original environmental cues
Note: Mutant mice showed impaired retrieval performance under partial cue conditions
View evidence from paper
“they were impaired in retrieving this memory when presented with a fraction of the original cues”