Morris Water Maze
Objective: Assess spatial learning and memory in mice to evaluate hippocampal-dependent cognition and detect progressive cognitive impairments
This is a Morris Water Maze protocol using mouse as the model organism. The procedure involves 2 procedural steps, 1 equipment items. Extracted from a 1999 paper published in Journal of Neuroscience.
Model and subjects
mouse • R6/2 transgenic and wild-type littermates • unknown • 3 to 14.5 weeks of age • Not specified
Study window
~14.5 week study window
Core workflow
Subject Assignment and Grouping • Morris Water Maze Testing
Primary readouts
- Spatial learning performance in Morris water maze
- Memory retention in Morris water maze
- Progressive cognitive decline with age
- Hippocampal-dependent function
Key equipment and reagents
Verified items
0
Direct vendor links
0
Use this page as an execution guide, then fall back to the source paper whenever you need exact exclusions, dosing details, or assay-specific caveats.
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Protocol Steps
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Subject Assignment and Grouping
Behavioral testing was performed on R6/2 transgenic mice and their wild-type littermates using separate groups of mice for each test
Note: Testing conducted between 3 and 14.5 weeks of age
View evidence from paper
“Behavioral testing was performed on R6/2 transgenic mice and their wild-type littermates between 3 and 14.5 weeks of age, using separate groups of mice for each test”
Morris Water Maze Testing
Mice navigate to a hidden platform in the water maze to assess spatial learning and memory
Note: Progressive deterioration in learning was observed between 3.5 and 8 weeks of age in R6/2 mice
View evidence from paper
“between 3.5 and 8 weeks of age, R6/2 mice displayed progressive deterioration in specific aspects of learning in the Morris water maze”