Morris Water Maze
behavioralmouserTg(tau P301L)4510 transgenic mice and nontransgenic age-matched control littermates
Objective: Longitudinal testing of spatial reference memory in transgenic mice to assess cognitive impairment with age using the Morris water maze
Materials & Equipment Checklist
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Equipment1
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Protocol Steps
1
Longitudinal Morris water maze testing
Spatial reference memory was tested longitudinally in rTg(tau P301L)4510 transgenic mice and nontransgenic age-matched control littermates using the Morris water maze
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Note: Testing began at 4 months of age and continued longitudinally with age
View evidence from paper
“the effects of tau P301L expression on spatial reference memory were longitudinally tested using the Morris water maze. Compared with nontransgenic age-matched control littermates, rTg(tau P301L)4510 mice developed significant cognitive impairments from 4 months of age”