Morris Water Maze
Objective: Longitudinal testing of spatial reference memory in transgenic mice to assess cognitive impairment with age using the Morris water maze
This is a Morris Water Maze protocol using mouse as the model organism. The procedure involves 1 procedural steps, 1 equipment items. Extracted from a 2005 paper published in Journal of Neuroscience.
Model and subjects
mouse • rTg(tau P301L)4510 transgenic mice and nontransgenic age-matched control littermates • Not specified • From 4 months of age onwards • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Longitudinal Morris water maze testing
Primary readouts
- Spatial reference memory performance
- Cognitive impairment development with age
- Memory deficits
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Longitudinal Morris water maze testing
Spatial reference memory was tested longitudinally in rTg(tau P301L)4510 transgenic mice and nontransgenic age-matched control littermates using the Morris water maze
Note: Testing began at 4 months of age and continued longitudinally with age
View evidence from paper
“the effects of tau P301L expression on spatial reference memory were longitudinally tested using the Morris water maze. Compared with nontransgenic age-matched control littermates, rTg(tau P301L)4510 mice developed significant cognitive impairments from 4 months of age”