Source Paper
Conditional Ablation of the Neural Cell Adhesion Molecule Reduces Precision of Spatial Learning, Long-Term Potentiation, and Depression in the CA1 Subfield of Mouse Hippocampus
Olena Bukalo, Nikolas Fentrop, Alan Y. W. Lee, Benedikt Salmen, Janice W. S. Law et al.
Journal of Neuroscience • 2004
Morris Water Maze
Objective: Assessment of spatial learning and memory through global landmark navigation in water maze, and evaluation of precision of spatial orientation acquisition
This is a Morris Water Maze protocol using mouse as the model organism. The procedure involves 1 procedural steps, 1 equipment items. Extracted from a 2004 paper published in Journal of Neuroscience.
Model and subjects
mouse • Not explicitly stated in provided text • unknown • Not explicitly stated in provided text • Not explicitly stated in provided text
Study window
Estimated timing pending
Core workflow
Water maze testing for spatial learning and memory
Primary readouts
- Short-term memory performance in water maze
- Long-term memory performance in water maze
- Precision of spatial orientation acquisition
- Global landmark navigation ability
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Water maze testing for spatial learning and memory
Mice were tested in a water maze to assess global landmark navigation abilities, short-term memory, long-term memory, and precision of spatial orientation acquisition
Note: NCAMff+ mutants showed delayed acquisition of precise spatial orientation compared to controls, but this deficit could be overcome by training
View evidence from paper
“did not show general deficits in short- and long-term memory in global landmark navigation in the water maze but were delayed in the acquisition of precise spatial orientation”