Source Paper
Conditional Ablation of the Neural Cell Adhesion Molecule Reduces Precision of Spatial Learning, Long-Term Potentiation, and Depression in the CA1 Subfield of Mouse Hippocampus
Olena Bukalo, Nikolas Fentrop, Alan Y. W. Lee, Benedikt Salmen, Janice W. S. Law et al.
Journal of Neuroscience • 2004
Morris Water Maze
Objective: Assessment of spatial learning and memory through global landmark navigation in water maze, and evaluation of precision of spatial orientation acquisition
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Equipment1
Not explicitly stated in provided text • Not mentioned • Not mentioned • Not mentioned
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Protocol Steps
Water maze testing for spatial learning and memory
Mice were tested in a water maze to assess global landmark navigation abilities, short-term memory, long-term memory, and precision of spatial orientation acquisition
Note: NCAMff+ mutants showed delayed acquisition of precise spatial orientation compared to controls, but this deficit could be overcome by training
View evidence from paper
“did not show general deficits in short- and long-term memory in global landmark navigation in the water maze but were delayed in the acquisition of precise spatial orientation”