Morris Water Maze - Reversal Learning
Objective: Evaluation of spatial learning and reversal learning in a water maze task to assess cognitive deficits in Shank3 null mutant mice
This is a Morris Water Maze - Reversal Learning protocol using mouse as the model organism. The procedure involves 2 procedural steps, 1 equipment items. Extracted from a 2012 paper published in Journal of Neuroscience.
Model and subjects
mouse • Shank3 null mutant and heterozygous mice • unknown • Not explicitly stated • Not explicitly stated
Study window
Estimated timing pending
Core workflow
Water Maze Spatial Learning Phase • Water Maze Reversal Learning Phase
Primary readouts
- Reversal learning performance in water maze
- Spatial learning ability
- Latency to platform
- Search patterns
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Water Maze Spatial Learning Phase
Mice were tested on initial spatial learning in the water maze task
Note: This phase precedes the reversal learning phase
View evidence from paper
“deficits in reversal of water maze learning were detected only in some cohorts”
Water Maze Reversal Learning Phase
Mice were tested on reversal learning in the water maze, where the platform location is changed from the initial learning phase
Note: Reversal learning deficits were detected only in some cohorts, emphasizing importance of replication
View evidence from paper
“deficits in reversal of water maze learning were detected only in some cohorts, emphasizing the importance of replication analyses”