Source Paper
Hyperactivity and Intact Hippocampus-Dependent Learning in Mice Lacking the M<sub>1</sub>Muscarinic Acetylcholine Receptor
Tsuyoshi Miyakawa, Masahisa Yamada, Alokesh Duttaroy, Jürgen Wess
Journal of Neuroscience • 2001
Morris Water Maze
Objective: Evaluation of spatial learning and hippocampus-dependent memory using a water navigation task in M1 receptor-deficient mice
This is a Morris Water Maze protocol using mouse as the model organism. The procedure involves 1 procedural steps, 1 equipment items. Extracted from a 2001 paper published in Journal of Neuroscience.
Model and subjects
mouse • M1 receptor-deficient mice (M1R−/− mice) • unknown • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Morris Water Maze Testing
Primary readouts
- Spatial learning performance
- Hippocampus-dependent memory
- Cognitive impairments (presence or absence)
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Morris Water Maze Testing
Subjects were subjected to Morris water maze testing as part of a battery of behavioral tests to assess spatial learning and hippocampus-dependent memory
Note: This test was conducted as part of comprehensive behavioral phenotyping of M1R−/− mice
View evidence from paper
“M1R−/− mice displayed no significant cognitive impairments in the Morris water maze and in contextual fear conditioning”