Full-Length Human Mutant Huntingtin with a Stable Polyglutamine Repeat Can Elicit Progressive and Selective Neuropathogenesis in BACHD Mice

M. Gray, D. I. Shirasaki, C. Cepeda, V. M. Andre, B. Wilburn et al.

Journal of Neuroscience • 2008

Motor Deficit Assessment

behavioralmouseBACHD (bacterial artificial chromosome-mediated transgenic)

Objective: Evaluation of progressive motor deficits in transgenic mice expressing full-length human mutant huntingtin

Evaluation of progressive motor deficits in BACHD transgenic mice

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Note: BACHD mice exhibit progressive motor deficits as part of their phenotype

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“BACHD mice exhibit progressive motor deficits, neuronal synaptic dysfunction, and late-onset selective neuropathology”