Motor Deficit Assessment
Objective: Evaluation of motor function changes and development of motor deficits in treated transgenic mice models of Huntington's disease
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Equipment1
Not specified • Not specified • Not specified • Not specified
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Protocol Steps
Motor deficit assessment initiation
Evaluation of motor function changes and development of motor deficits in transgenic mice
Note: Assessment conducted in R6/2 and N171-82Q transgenic mouse models of Huntington's disease
View evidence from paper
“Evaluation of motor function changes and development of motor deficits in treated transgenic mice”
Treatment administration
Oral administration of coenzyme Q10 and/or remacemide to transgenic mice
Note: Combined treatment was more efficacious than either compound alone
View evidence from paper
“oral administration of either coenzyme Q 10 or remacemide significantly extended survival and delayed the development of motor deficits”
Motor deficit monitoring
Continuous monitoring of motor deficit development in treated and control transgenic mice
Note: Motor deficits were delayed in treated groups compared to controls
View evidence from paper
“delayed the development of motor deficits, weight loss, cerebral atrophy, and neuronal intranuclear inclusions”
Magnetic resonance imaging assessment
In vivo imaging to assess ventricular enlargement and cerebral atrophy
Note: Combined treatment significantly attenuated ventricular enlargement
View evidence from paper
“Magnetic resonance imaging showed that combined treatment significantly attenuated ventricular enlargement in vivo”