Motor Deficit Assessment
Objective: Evaluation of motor function changes and development of motor deficits in treated transgenic mice models of Huntington's disease
This is a Motor Deficit Assessment protocol using mouse as the model organism. The procedure involves 4 procedural steps, 1 equipment items, 2 materials. Extracted from a 2002 paper published in Journal of Neuroscience.
Model and subjects
mouse • R6/2 transgenic and N171-82Q transgenic • unknown • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Motor deficit assessment initiation • Treatment administration • Motor deficit monitoring
Primary readouts
- Motor deficit development and severity
- Survival time
- Weight loss
- Cerebral atrophy
Key equipment and reagents
Use this page as an execution guide, then fall back to the source paper whenever you need exact exclusions, dosing details, or assay-specific caveats.
Confirm first
- Verify the animal model, intervention setup, and collection timepoints against the source paper.
- Check that every direct vendor link matches the exact specification your lab plans to run.
Use the page like this
- Work through the protocol steps in order and use the inline vendor chips only when you need to source or verify an item.
- Jump to Experimental Context for readouts, data shape, and analysis flow before planning downstream analysis.
Protocol Steps
Start here. The step list is optimized for running the experiment, with direct vendor links available inline when you need to source a cited item.
Motor deficit assessment initiation
Evaluation of motor function changes and development of motor deficits in transgenic mice
Note: Assessment conducted in R6/2 and N171-82Q transgenic mouse models of Huntington's disease
View evidence from paper
“Evaluation of motor function changes and development of motor deficits in treated transgenic mice”
Treatment administration
Oral administration of coenzyme Q10 and/or remacemide to transgenic mice
Note: Combined treatment was more efficacious than either compound alone
View evidence from paper
“oral administration of either coenzyme Q 10 or remacemide significantly extended survival and delayed the development of motor deficits”
Motor deficit monitoring
Continuous monitoring of motor deficit development in treated and control transgenic mice
Note: Motor deficits were delayed in treated groups compared to controls
View evidence from paper
“delayed the development of motor deficits, weight loss, cerebral atrophy, and neuronal intranuclear inclusions”
Magnetic resonance imaging assessment
In vivo imaging to assess ventricular enlargement and cerebral atrophy
Note: Combined treatment significantly attenuated ventricular enlargement
View evidence from paper
“Magnetic resonance imaging showed that combined treatment significantly attenuated ventricular enlargement in vivo”