Motor Deficit Assessment
Objective: Evaluation of motor deficits in HD140Q-knockin mice following CRISPR/Cas9-mediated reduction of mHTT expression in the striatum
This is a Motor Deficit Assessment protocol using mouse as the model organism. The procedure involves 1 procedural steps. Extracted from a 2017 paper published in Journal of Clinical Investigation.
Model and subjects
mouse • HD140Q-knockin mice • unknown • adult • not specified
Study window
Estimated timing pending
Core workflow
Motor Deficit Assessment
Primary readouts
- Motor deficit severity
- Motor function improvement following mHTT reduction
- Neuronal viability in striatum
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Motor Deficit Assessment
Evaluation of motor deficits in HD140Q-knockin mice following CRISPR/Cas9-mediated reduction of mHTT expression
Note: The reduction of mHTT expression in striatal neuronal cells in adult HD140Q-knockin mice alleviated motor deficits
View evidence from paper
“The reduction of mHTT expression in striatal neuronal cells in adult HD140Q-knockin mice did not affect viability, but alleviated motor deficits”