Motor Deficit Assessment
behavioralmouseHD140Q-knockin mice
Objective: Evaluation of motor deficits in HD140Q-knockin mice following CRISPR/Cas9-mediated reduction of mHTT expression in the striatum
Protocol Steps
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Motor Deficit Assessment
Evaluation of motor deficits in HD140Q-knockin mice following CRISPR/Cas9-mediated reduction of mHTT expression
not specifiednot specified
Note: The reduction of mHTT expression in striatal neuronal cells in adult HD140Q-knockin mice alleviated motor deficits
View evidence from paper
“The reduction of mHTT expression in striatal neuronal cells in adult HD140Q-knockin mice did not affect viability, but alleviated motor deficits”