Motor Function Assessment
Objective: Assess motor function and kinematic performance regularly for 6 months after stroke in mice with BDNF Val66Met polymorphism
Protocol Steps
Surgical intervention
Male BDNF +/+ and BDNF M/M littermates received either sham surgery or transient middle cerebral artery occlusion
Note: Two experimental groups: sham and stroke
View evidence from paper
“Male BDNF +/+ and BDNF M/M littermates received sham or transient middle cerebral artery occlusion”
Motor function assessment
Regular assessment of motor function and kinematic performance conducted over 6 months following stroke or sham surgery
Note: Assessment was conducted regularly throughout the 6-month period
View evidence from paper
“We assessed motor function regularly for 6 months after stroke”
Anatomical analysis
Performed anatomical analyses after the 6-month assessment period
Note: Conducted following completion of motor function assessments
View evidence from paper
“and then performed anatomical analyses”
Transient inactivation study
Transient inactivation of the contralateral striatum during recovery to test its role in enhanced motor function
Note: This manipulation transiently abolished the enhanced function
View evidence from paper
“Transient inactivation of the contralateral striatum during recovery transiently abolished the enhanced function”