Experiments/Motor Function Assessment

Source Paper

An Adaptive Role for BDNF Val66Met Polymorphism in Motor Recovery in Chronic Stroke

Luye Qin, Deqiang Jing, Sarah Parauda, Jason Carmel, Rajiv R. Ratan et al.

Journal of Neuroscience • 2014

DOI PMC

Motor Function Assessment

behavioralmouseBDNF +/+ and BDNF M/M littermates

Objective: Assess motor function and kinematic performance regularly for 6 months after stroke in mice with BDNF Val66Met polymorphism

This is a Motor Function Assessment protocol using mouse as the model organism. The procedure involves 4 procedural steps. Extracted from a 2014 paper published in Journal of Neuroscience.

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Replication Essentials

Model and subjects

mouse • BDNF +/+ and BDNF M/M littermates • unknown • Not specified • Not specified

Study window

Estimated timing pending

Core workflow

Surgical intervention • Motor function assessment • Anatomical analysis

Primary readouts

Motor function performance
Kinematic performance
Ipsilesional hindlimb function
Striatum volume

Key equipment and reagents

Procurement Snapshot

Verified items

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Protocol Steps

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Surgical intervention

Male BDNF +/+ and BDNF M/M littermates received either sham surgery or transient middle cerebral artery occlusion

Not specifiedNot specified

Note: Two experimental groups: sham and stroke

View evidence from paper

“Male BDNF +/+ and BDNF M/M littermates received sham or transient middle cerebral artery occlusion”