Open Field Activity Test
Objective: Assessment of non-social exploratory activity and motor functions in response to MPEP and risperidone treatment
Gather these items before starting the experiment. Check off items as you prepare.
Equipment1
Not specified • Not specified • Not specified • Not specified
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Protocol Steps
Open field activity testing
Mice were tested in open field arena to assess non-social exploratory activity and motor functions as a control measure
Note: This test served as an independent control for evaluating sedating effects of treatments
View evidence from paper
“Open field activity served as an independent control for non-social exploratory activity and motor functions”
MPEP treatment evaluation
MPEP was administered to BTBR mice at doses that did not induce sedation in open field activity
Note: MPEP significantly reduced repetitive self-grooming without sedating effects
View evidence from paper
“MPEP significantly reduced repetitive self-grooming in BTBR, at doses that had no sedating effects on open field activity”
Risperidone treatment evaluation
Risperidone was administered to BTBR mice at doses that induced sedation in both strains
Note: Risperidone reduced repetitive self-grooming but only at doses that induced sedation
View evidence from paper
“Risperidone reduced repetitive self-grooming in BTBR, but only at doses that induced sedation in both strains”