Open Field Activity Test
Objective: Assessment of non-social exploratory activity and motor functions in response to MPEP and risperidone treatment
This is a Open Field Activity Test protocol using mouse as the model organism. The procedure involves 3 procedural steps, 1 equipment items, 2 materials. Extracted from a 2009 paper published in Neuropsychopharmacology.
Model and subjects
mouse • BTBR T+tf/J (BTBR) and C57BL/6J (B6) • unknown • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Open field activity testing • MPEP treatment evaluation • Risperidone treatment evaluation
Primary readouts
- Non-social exploratory activity
- Motor function
- Sedation effects
- Repetitive self-grooming behavior
Key equipment and reagents
Use this page as an execution guide, then fall back to the source paper whenever you need exact exclusions, dosing details, or assay-specific caveats.
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- Verify the animal model, intervention setup, and collection timepoints against the source paper.
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Protocol Steps
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Open field activity testing
Mice were tested in open field arena to assess non-social exploratory activity and motor functions as a control measure
Note: This test served as an independent control for evaluating sedating effects of treatments
View evidence from paper
“Open field activity served as an independent control for non-social exploratory activity and motor functions”
MPEP treatment evaluation
MPEP was administered to BTBR mice at doses that did not induce sedation in open field activity
Note: MPEP significantly reduced repetitive self-grooming without sedating effects
View evidence from paper
“MPEP significantly reduced repetitive self-grooming in BTBR, at doses that had no sedating effects on open field activity”
Risperidone treatment evaluation
Risperidone was administered to BTBR mice at doses that induced sedation in both strains
Note: Risperidone reduced repetitive self-grooming but only at doses that induced sedation
View evidence from paper
“Risperidone reduced repetitive self-grooming in BTBR, but only at doses that induced sedation in both strains”