GABA Transporter Deficiency Causes Tremor, Ataxia, Nervousness, and Increased GABA-Induced Tonic Conductance in Cerebellum

Chi-Sung Chiu, Stephen Brickley, Kimmo Jensen, Amber Southwell, Sheri Mckinney et al.

Journal of Neuroscience • 2005

DOI PMC

Open Field Test

behavioralmouseGAT1 knockout (mGAT1 KO) mice

Objective: Evaluation of exploratory activity, anxiety-like behavior, and locomotor activity in GAT1 knockout mice

Materials & Equipment Checklist

1 item

Gather these items before starting the experiment. Check off items as you prepare.

Equipment1

Open-field test apparatus

Not specified • Not specified • Not specified • Not specified

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Protocol Steps

Open-field test administration

Mice were placed in an open-field arena to assess exploratory behavior, anxiety-like responses, and locomotor activity

Not specifiedNot specified

Note: The test measured delayed exploratory activity, rearing behavior, visits to central area, and total distance traveled

View evidence from paper

“Open-field tests show delayed exploratory activity, reduced rearing, and reduced visits to the central area, with no change in the total distance traveled”