Source Paper
Dopamine D4 Receptor-Knock-Out Mice Exhibit Reduced Exploration of Novel Stimuli
Stephanie C. Dulawa, David K. Grandy, Malcolm J. Low, Martin P. Paulus, Mark A. Geyer
Journal of Neuroscience • 1999
Open Field Test
Objective: Assessment of exploratory behavior and anxiety-related responses in an open field arena to evaluate novelty responses in mice
This is a Open Field Test protocol using mouse as the model organism. The procedure involves 1 procedural steps, 1 equipment items. Extracted from a 1999 paper published in Journal of Neuroscience.
Model and subjects
mouse • D4R-knock-out (D4R−/−) and wild-type (D4R+/+)
Study window
Estimated timing pending
Core workflow
Open Field Test
Primary readouts
- Behavioral responsiveness to novelty
- Exploratory behavior
- Anxiety-related behavior
- Approach-avoidance conflict responses
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Open Field Test
Mice were evaluated in the open field test, which is one of three approach-avoidance paradigms used to assess behavioral responses to novelty. The open field test maximizes avoidance behavior relative to approach behavior.
Note: The open field test showed the smallest phenotypic differences between D4R−/− and D4R+/+ mice compared to other tests
View evidence from paper
“we evaluated D4R-knock-out (D4R−/−) and wild-type (D4R+/+) mice in three approach–avoidance paradigms: the open field, emergence, and novel object tests”