Pain Sensitivity Measurement
behavioralmousetransgenic mice overexpressing human COMT-Val polymorphism (Val-tg) and COMT-null mutant mice
Objective: Assessed pain sensitivity in transgenic mice overexpressing COMT-Val and COMT-null mutant mice to determine the role of COMT gene in pain sensitivity and stress responses
Protocol Steps
1
Pain Sensitivity Assessment
Pain sensitivity was assessed in transgenic mice overexpressing COMT-Val and COMT-null mutant mice. The study found that increased COMT enzyme activity in Val-tg mice resulted in blunted pain sensitivity, while COMT disruption increased pain sensitivity.
not specifiednot specified
Note: Specific pain sensitivity testing methodology (e.g., hot plate test, tail flick test, von Frey filaments) is not detailed in the provided text
View evidence from paper
“Increased COMT enzyme activity in Val-tg mice resulted in disrupted attentional set-shifting abilities, and impaired working and recognition memory, but blunted stress responses and pain sensitivity. Conversely, COMT disruption improved working memory, but increased stress responses and pain sensitivity.”