Source Paper
Reduction in Mitochondrial Superoxide Dismutase Modulates Alzheimer's Disease-Like Pathology and Accelerates the Onset of Behavioral Changes in Human Amyloid Precursor Protein Transgenic Mice
Luke Esposito, Jacob Raber, Lisa Kekonius, Fengrong Yan, Giu-Qiu Yu et al.
Journal of Neuroscience • 2006
Prepulse Inhibition of Acoustic Startle
Objective: Measurement of sensorimotor gating through prepulse inhibition of acoustic startle response in hAPP mice to assess behavioral alterations and neurological deficits
This is a Prepulse Inhibition of Acoustic Startle protocol using mouse as the model organism. The procedure involves 1 procedural steps, 1 equipment items. Extracted from a 2006 paper published in Journal of Neuroscience.
Model and subjects
mouse • human amyloid precursor protein (hAPP) transgenic mice • unknown • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Prepulse Inhibition Testing
Primary readouts
- Prepulse inhibition of acoustic startle response
- Sensorimotor gating deficits
- Behavioral alterations onset timing
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Prepulse Inhibition Testing
Mice were tested for prepulse inhibition of acoustic startle response as a measure of sensorimotor gating
Note: This test was used to assess behavioral alterations in hAPP transgenic mice with reduced Sod2 activity
View evidence from paper
“deficits in prepulse inhibition of acoustic startle, a measure of sensorimotor gating”