Prepulse Inhibition and Acoustic Startle Test
Objective: Measurement of sensorimotor gating through assessment of prepulse inhibition and habituation to acoustic startle stimuli in YAC128 mice
This is a Prepulse Inhibition and Acoustic Startle Test protocol using mouse as the model organism. The procedure involves 1 procedural steps, 1 equipment items. Extracted from a 2005 paper published in Journal of Neuroscience.
Model and subjects
mouse • YAC128 • unknown • 12 months • not specified
Study window
Estimated timing pending
Core workflow
Prepulse Inhibition and Acoustic Startle Testing
Primary readouts
- Prepulse inhibition response
- Habituation to acoustic startle
- Startle response magnitude
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Prepulse Inhibition and Acoustic Startle Testing
YAC128 mice and wild-type controls were tested for prepulse inhibition and habituation to acoustic startle stimuli at 12 months of age
Note: Testing was conducted to assess sensorimotor gating deficits in the YAC128 mouse model of Huntington's disease
View evidence from paper
“At 12 months of age, YAC128 mice show decreased prepulse inhibition and habituation to acoustic startle.”