Source Paper
α7 Nicotinic Receptor Subunits Are Not Necessary for Hippocampal-Dependent Learning or Sensorimotor Gating: A Behavioral Characterization of <i>Acra7</i>-Deficient Mice
Richard Paylor, Michelle Nguyen, Jacqueline N. Crawley, James Patrick, Arthur Beaudet et al.
Learning & Memory • 1998
Prepulse Inhibition Paradigm
Objective: Measurement of sensorimotor gating through prepulse inhibition of startle response in mice
This is a Prepulse Inhibition Paradigm protocol using mouse as the model organism. The procedure involves 1 procedural steps, 1 equipment items. Extracted from a 1998 paper published in Learning & Memory.
Model and subjects
mouse • Acra7 homozygous mutant mice and wild-type littermates • unknown • Not specified • Not specified
Study window
Estimated timing pending
Core workflow
Prepulse Inhibition Testing
Primary readouts
- Prepulse inhibition levels
- Startle habituation
- Sensorimotor gating responses
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Prepulse Inhibition Testing
Acra7 mutant mice and wild-type littermates were tested in the prepulse inhibition paradigm to measure sensorimotor gating
Note: This was one of three behavioral tests conducted on the animals
View evidence from paper
“Acra7 homozygous mutant mice and their wild-type littermates were tested in a Pavlovian conditioned fear test, for spatial learning in the Morris water task, and in the prepulse inhibition paradigm”