Prepulse Inhibition (PPI) Test
Objective: Assessment of sensorimotor gating by measuring the ability to inhibit startle response when preceded by a prepulse stimulus
This is a Prepulse Inhibition (PPI) Test protocol using mouse as the model organism. The procedure involves 1 procedural steps. Extracted from a 2007 paper published in Journal of Neuroscience.
Model and subjects
mouse • Not specified in provided text • unknown • adult offspring • Not specified in provided text
Study window
Estimated timing pending
Core workflow
Prepulse Inhibition Testing
Primary readouts
- Prepulse inhibition (PPI) response
- Startle response inhibition
- Sensorimotor gating ability
Key equipment and reagents
Verified items
0
Direct vendor links
0
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Protocol Steps
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Prepulse Inhibition Testing
Conduct prepulse inhibition (PPI) test to assess sensorimotor gating in adult offspring
Note: PPI is measured as the ability to inhibit startle response when preceded by a prepulse stimulus
View evidence from paper
“A single maternal injection of IL-6 on day 12.5 of mouse pregnancy causes prepulse inhibition (PPI) and latent inhibition (LI) deficits in the adult offspring”